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Abstract #2932

            Proton magnetic resonance spectroscopy (1H-MRS) in degenerative cervical spinal cord compression.

Petr Bednarik1, Tomas Horak2, Magda Horakova3, Alena Svatkova4, Zdenek Kadanka3, Zdenek Kadanka jr3, Petr Kudlicka5, Jan Valosek6, Dinesh Deelchand7, Pierre-Gilles Henry7, and Josef Bednarik3
1Departement of Medical Imaging and Image-guided Therapy, High Field MR Center, Vienna, Austria, 2Masaryk University, Brno, Czech Republic, 3Department of Neurology, University Hospital Brno, Brno, Czech Republic, 4Department of Internal Medicine, Medical University of Vienna, Vienna, Austria, 5Multimodal and Functional Imaging Laboratory, Central European Institute of Technology, Brno, Czech Republic, 6Departments of Neurology and Biomedical Engineering, University Hospital Olomouc, Olomouc, Czech Republic, 7Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

While cervical spinal cord (CSC) compression occurs almost ubiquitously with aging, early metabolic changes in CSC that might develop into irreversible clinical myelopathy symptoms have not been described yet. Thus, we utilized fine-tuned semi-LASER 3T MRS protocol that addresses limitations of standard MRS methods to unravel metabolic damage in the cranial parts of the CSC in 50 patients with non-myelopathic degenerative cervical cord compression and 10 with clinically symptomatic degenerative cervical myelopathy in comparison to 35 healthy controls. Higher tNAA/tCr and myo-Ins/tNAA levels suggest axonal loss above the level of stenosis, indicating that CSC impairment exceeds the level of compression.

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