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Abstract #2938

Effects of lisinopril on arterial stiffness, hippocampal blood flow, N-acetyl aspartate and cortical thickness in hypertensive Dahl-s rats

Samuel Ajamu1, Rachel Fenner1, Nikkita Khattar2, Yulia Grigorova1, Edward Lakatta1, Ondrej Juhasz1, Peter Rapp3, Mustapha Bouhrara2, Richard Spencer2, Olga Fedorova1, and Kenneth Fishbein2
1Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, MD, United States, 2Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, United States, 3National Institute on Aging, Baltimore, MD, United States

Central arterial stiffness (CAS), associated with hypertension, is likely associated with attendant cerebral hypoperfusion, neuronal density loss and cognitive decline, and stiffening of cerebral arterial wall. We previously found associations between pulse wave velocity (PWV), a marker of CAS, and hippocampal cerebral blood flow (CBF) and neuronal density in 6 months old hypertensive Dahl salt-sensitive (Dahl-S) rats, which exhibit age-associated memory loss. The present study showed the ACE inhibitor, lisinopril, resulted in stabilized hippocampal blood flow and NAA concentration compared to nontreated age-matched animals. We also observed significant changes in cortical thickness for treated animals compared to nontreated control.

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