Abstract #2938

Effects of lisinopril on arterial stiffness, hippocampal blood flow, N-acetyl aspartate and cortical thickness in hypertensive Dahl-s rats

Samuel Ajamu¹, Rachel Fenner¹, Nikkita Khattar², Yulia Grigorova¹, Edward Lakatta¹, Ondrej Juhasz¹, Peter Rapp³, Mustapha Bouhrara², Richard Spencer², Olga Fedorova¹, and Kenneth Fishbein²

¹Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, MD, United States, ²Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, United States, ³National Institute on Aging, Baltimore, MD, United States

Central arterial stiffness (CAS), associated with hypertension, is likely associated with attendant cerebral hypoperfusion, neuronal density loss and cognitive decline, and stiffening of cerebral arterial wall. We previously found associations between pulse wave velocity (PWV), a marker of CAS, and hippocampal cerebral blood flow (CBF) and neuronal density in 6 months old hypertensive Dahl salt-sensitive (Dahl-S) rats, which exhibit age-associated memory loss. The present study showed the ACE inhibitor, lisinopril, resulted in stabilized hippocampal blood flow and NAA concentration compared to nontreated age-matched animals. We also observed significant changes in cortical thickness for treated animals compared to nontreated control.

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