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Abstract #2939

Association of multiple sclerosis central fatigue with inhibitory and excitatory neurotransmitters

Jameen ARM1,2, Georg Oeltzschner3,4, Oun Al-Iedani1,2, Rodney Lea5,6, Jeannette Lechner-Scott5,7,8, and Sadallah Ramadan1,5
1School of Health Sciences, University of Newcastle, Newcastle, Australia, 2Imaging centre, Hunter Medical Research Institute, Newcastle, Australia, 3The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 5HMRI Imaging centre, Hunter Medical Research Institute, Newcastle, Australia, 6School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia, 7Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia, 8Department of Neurology, John Hunter Hospital, Newcastle, Australia

Despite neuro metabolic and morphological alterations linked to central fatigue in multiple sclerosis (MS), the pathophysiology of this symptom is not fully understood. Dysfunction of the GABAergic/Glutamatergic pathways involving inhibitory and excitatory neurotransmitters such as γ-aminobutyric acid (GABA) and glutamine+glutamate pools (Glx) have been implicated in several neurological disorders, including MS. In this study, we evaluated if GABA and Glx levels are associated with central fatigue in MS. Our results showed significant correlations of GABA and Glx levels with fatigue scores which suggest dysregulation of GABAergic/glutamatergic neurotransmission is possibly implicated in the mechanisms of mediating central fatigue in MS

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