Abstract #2943

Simultaneous characterization of individual macromolecule resonances and metabolites in the Fischer 344 rat during healthy aging

Caitlin Fowler¹, Dan Madularu², Masoumeh Dehghani², Gabriel Devenyi², and Jamie Near³

¹Biological and Biomedical Engineering, McGill University - Douglas Hospital Research Centre, Verdun, QC, Canada, ²Douglas Hospital Research Centre, Verdun, QC, Canada, ³Psychiatry, McGill University - Douglas Hospital Research Centre, Montréal, QC, Canada

To better understand pathological aging, we must first have a thorough understanding of changes that occur in the brain during healthy aging. This project employs Magnetic Resonance Spectroscopy to characterize longitudinal changes in the neurochemical profile of healthy Fischer 344 rats. In addition to the commonly reported metabolites, nine macromolecular resonances were included in the basis set and quantified, based on parameterization of a group-averaged metabolite-nulled spectrum. For the first time, longitudinal age-related changes in metabolites and individual macromolecules were simultaneously characterized in the Fischer rat. Sex-specific differences were also identified in metabolites and macromolecules.

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