Meeting Banner
Abstract #2944

Effects of  High Fat Diet  on the adipose tissues and brain metabolism of a transgenic mouse which over-expresses human hydrolase hMTH1

Rossella Canese1, Gabriele De Luca2, Ambra Dell'Orso3, Egidio Iorio1, Mattea Chirico1, Maria Elena Pisanu1, Paola Fortini3, and Valeria Simonelli3
1NMR and MRI unit, Core facilities, Istituto Superiore di Sanita', Rome, Italy, 2Oncology and Molecular Medicine Department, Istituto Superiore di Sanita', Rome, Italy, 3Environmental and Health department, Istituto Superiore di Sanita', Rome, Italy

Oxidative stress is implicated in the pathogenesis of cancer, neurodegeneration and aging. hMTH1 is a hydrolase able to protect cells by oxidative damage. Overexpression of hMTH1 in transgenic mice (hMTH1‐Tg) confers significant protection against neurodegeneration and motor impairment. In this study, we use the hMTH1‐Tg mouse model and we found that oxidative damage is able to affect brain metabolism and adipose organ composition and extension. Moreover, we investigated the protective role of hMTH1-tg against an environmental oxidative stimulus like the assumption of a diet at high content of fat.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here