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Abstract #2945

Effects of Housing, Age, Strain, and Signal to Noise Ratio on Magnetic Resonance Spectroscopy in the Rat Brain

Wendy Oakden1 and Greg J Stanisz1,2,3
1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Lublin, Poland

Changes in metabolite levels as a result of treatment can be quite small. This study investigated the variability of MRS detectable metabolites so that the effects relating to the treatment would not be confounded by other experimental factors. A four-way ANOVA was used to separate the effects of differences in housing conditions (single housing, pairs, or enriched environment) as well as age (5-15 weeks), strain (Long Evans vs Sprague Dawley), and SNR. Significant changes in MRS were observed due to age, strain, and SNR, but any changes due to housing conditions were small in comparison.

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