Evaluating Apparent T2* values of Metabolites in Healthy Adults and Youths using TIDEL-COSY

For decades, one-dimensional (1D) spectroscopy has aided in the diagnosis of several pathologies. However, 1D approaches suffer from severe spectral overlap, possibly limiting their application. Two-dimensional (2D) spectroscopy allows for greater spectral separation, and many studies have successfully quantified metabolites with the localized correlated spectroscopy (L-COSY). Here, we combine the L-COSY technique with a T2* weighted deconvolution (TIDE) approach and develop the TIDEL-COSY method. We show the capability of the novel TIDEL-COSY method and compare the apparent T2* values between healthy youths and adults for a variety of metabolites.