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Abstract #2946

Evaluating Apparent T2* values of Metabolites in Healthy Adults and Youths using TIDEL-COSY

Zohaib Iqbal1, Rajakumar Nagarajan2, Manoj Sarma3, Andres Saucedo3, and Michael Albert Thomas3
1Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, United States, 2Human Magnetic Resonance Center, UMass, Amherst, MA, United States, 3UCLA, Los Angeles, CA, United States

For decades, one-dimensional (1D) spectroscopy has aided in the diagnosis of several pathologies. However, 1D approaches suffer from severe spectral overlap, possibly limiting their application. Two-dimensional (2D) spectroscopy allows for greater spectral separation, and many studies have successfully quantified metabolites with the localized correlated spectroscopy (L-COSY). Here, we combine the L-COSY technique with a T2* weighted deconvolution (TIDE) approach and develop the TIDEL-COSY method. We show the capability of the novel TIDEL-COSY method and compare the apparent T2* values between healthy youths and adults for a variety of metabolites.

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