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Abstract #2947

Detection of beta-hydroxybutyrate in human brain after oral administration of a ketone ester

Jan Willem van der Veen1, Corinde Wiers2, and Jun Shen3
1Magnetic Resonance Spectroscopy Core, NIMH, NIH, Bethesda, MD, United States, 2NIH, NIAAA, Bethesda, MD, United States, 3Magnetic Resonance Spectroscopy Core, NIH, NIMH, Bethesda, MD, United States

Beta-Hydroxybutyrate (BHB) is a marker of metabolic ketosis in brain. To study ketogenic treatment spectral editing was developed to invert the signals in the 3.2-4.6 ppm spectral region for detecting BHB and co-edited signals. Using this spectral editing technique we found markedly elevated BHB signal in the human brain shortly after oral administration of 1,3-butanediol monoester of beta-hydroxybutyrate as compared to the control scan without consumption of the ketone ester.

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