Abstract #2947

Detection of beta-hydroxybutyrate in human brain after oral administration of a ketone ester

Jan Willem van der Veen¹, Corinde Wiers², and Jun Shen³

¹Magnetic Resonance Spectroscopy Core, NIMH, NIH, Bethesda, MD, United States, ²NIH, NIAAA, Bethesda, MD, United States, ³Magnetic Resonance Spectroscopy Core, NIH, NIMH, Bethesda, MD, United States

Beta-Hydroxybutyrate (BHB) is a marker of metabolic ketosis in brain. To study ketogenic treatment spectral editing was developed to invert the signals in the 3.2-4.6 ppm spectral region for detecting BHB and co-edited signals. Using this spectral editing technique we found markedly elevated BHB signal in the human brain shortly after oral administration of 1,3-butanediol monoester of beta-hydroxybutyrate as compared to the control scan without consumption of the ketone ester.

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