MRS allows non-invasive in-vivo exploration of tissue metabolism. However, about half of the proton spectrum (downfield of water) has been nearly ignored over the decades of MRS application due to water suppression. We show that ISIS-based Relaxation Enhanced MRS (iRE-MRS) which uses frequency selective excitation and ISIS localization offers short echo times and enhances exchange-broadened resonances. For the first time, we measure in-vivo downfield spectra in mouse glioma tumors (and controls) and show remarkable spectral signatures for the tumor downfield.
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