Abstract #2949

MR Spectroscopic Differences of Low and High Grade TERTp-only Gliomas

Banu Sacli-Bilmez¹, Ayhan Gursan², Ayca Ersen Danyeli³, Cengiz Yakicier⁴, M.Necmettin Pamir^5,6, Koray Ozduman^5,6, Alp Dincer^5,7, and Esin Ozturk-Isik¹

¹Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, ²Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ³Department of Medical Pathology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ⁴Department of Molecular Biology and Genetics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ⁵Center for Neuroradiological Applications and Reseach, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ⁶Department of Neurosurgery, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ⁷Department of Radiology, Acıbadem Mehmet Ali Aydinlar University, Istanbul, Turkey

Gliomas that only have the telomerase reverse transcriptase promoter mutation (TERTp-only) are known to have the worst overall survival. The aim of this study was to analyze magnetic resonance spectroscopic (MRS) differences of different grades of TERTp-only gliomas, and classify these groups using machine learning. The results indicated that the ratios of glycerophosphocholine (GPC), glutathione (GSH), total choline (tCho), and glutamine and glutamate complex (Glx) to total creatine increased along with the tumor grade, and machine learning models classified low- and high-grade TERTp-only gliomas with a high accuracy.

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