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Abstract #2950

GSH and GABA decreases in IDH1 mutated low-grade gliomas detected by HERMES spectral editing at 3 T in vivo

Tao Gong1, Richard Edden2,3, and Guangbin Wang1
1Shandong Medical Imaging Research Institute, Jinan, China, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

IDH1 mutation could result in better prognosis compared with wild-type, but the mechanisms remain largely unknown. GABA and GSH are low-concentration metabolites, could not be detected using conventional MRS, but playing an important role in energy production of glioma. HERMES can be thought of as two MEGA-PRESS experiments with the benefit of saving half the acquisition time to simultaneously detect GABA and GSH. The results demonstrated that HERMES is a reliable tool for the simultaneous detection of GABA and GSH signals, and both of them decreased significantly in IDH1 mutated low-grade gliomas.

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