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Abstract #2952

Identification of Potential Biomarkers for Human Esophageal Cancer: NMR-based metabolomics of paired tissue-serum samples

Yan Lin1, Wei Ye1, Jiayun Zhao1, Ouyang Ting1, and Wan Tang1
1Radiology Department, Second Affiliated Hospital of Shantou University Medical College, Shantou City, China

This was a parallel investigation of esophageal tumor tissues and adjacent normal mucosal tissues alongside patient-matched serum samples by nuclear magnetic resonance (NMR)-based metabolomics, to investigate how serum metabolic phenotypes were linked to the changes in the biochemical landscape of esophageal tumors. These associations provide evidence of distinct metabolic signatures and pathway disturbances between tumor tissues and serum of esophageal cancer patients, and changes in serum metabolic signature could reflect reprogramming of the aforementioned metabolic pathways in EC tissues.

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