Abstract #2953

Metabolic Differences in Blood Plasma of Type 2 Diabetic and Non-diabetic Prostate Cancer Patients using NMR Spectroscopy

Virendra Kumar¹, Pradeep Kumar¹, Rajeev Kumar², Sanjay Sharma³, Sanjay Thulkar⁴, Siddhartha Dattagupta⁵, S Senthil Kumaran¹, Rama Jayasundar¹, and N R Jagannathan⁶

¹Department of NMR, All India Institute of Medical Sciences, New Delhi, India, ²Department of Urology, All India Institute of Medical Sciences, New Delhi, India, ³Department of Radio-diagnosis, RPC, All India Institute of Medical Sciences, New Delhi, India, ⁴Department of Radio-diagnosis, IRCH, All India Institute of Medical Sciences, New Delhi, India, ⁵Department of Pathology, All India Institute of Medical Sciences, New Delhi, India, ⁶Present address: Department of Radiology, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India

The present study evaluates the metabolic profile of blood plasma for distinguishing prostate cancer (PCa) patients with type 2 diabetes mellitus (T2DM), PCa and healthy controls using ¹H-NMR spectroscopy. Our data showed significant lower concentration of glycine, glycerophosphocholine, choline and higher concentration of glucose in PCa patients with T2DM as compared to PCa patients and healthy control. Results provided an insight into the alterations in the metabolic pathways in T2DM-PCa and indicated that NMR spectroscopy may help in determining metabolic changes associated with PCa patients with T2DM and may help in diagnosis.

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