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Abstract #2953

Metabolic Differences in Blood Plasma of Type 2 Diabetic and Non-diabetic Prostate Cancer Patients using NMR Spectroscopy

Virendra Kumar1, Pradeep Kumar1, Rajeev Kumar2, Sanjay Sharma3, Sanjay Thulkar4, Siddhartha Dattagupta5, S Senthil Kumaran1, Rama Jayasundar1, and N R Jagannathan6
1Department of NMR, All India Institute of Medical Sciences, New Delhi, India, 2Department of Urology, All India Institute of Medical Sciences, New Delhi, India, 3Department of Radio-diagnosis, RPC, All India Institute of Medical Sciences, New Delhi, India, 4Department of Radio-diagnosis, IRCH, All India Institute of Medical Sciences, New Delhi, India, 5Department of Pathology, All India Institute of Medical Sciences, New Delhi, India, 6Present address: Department of Radiology, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India

The present study evaluates the metabolic profile of blood plasma for distinguishing prostate cancer (PCa) patients with type 2 diabetes mellitus (T2DM), PCa and healthy controls using 1H-NMR spectroscopy. Our data showed significant lower concentration of glycine, glycerophosphocholine, choline and higher concentration of glucose in PCa patients with T2DM as compared to PCa patients and healthy control. Results provided an insight into the alterations in the metabolic pathways in T2DM-PCa and indicated that NMR spectroscopy may help in determining metabolic changes associated with PCa patients with T2DM and may help in diagnosis.

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