Abstract #2955

Metabolic Characterization of Pre-Surgical Lower Grade Glioma Using Spectroscopic Imaging Optimized for 2-HG Detection

Marisa Lafontaine¹, Adam Autry¹, Llewellyn Jalbert¹, Elizabeth Phillips¹, Susan Chang², and Yan Li¹

¹Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, ²Neurological Surgery, UCSF, San Francisco, CA, United States

2-HG optimized MR spectroscopic imaging showed 2HG was detected in 37 out of 40 IDH1+ patients. Although it was not significantly different between IDH+ and IDH- gliomas, significant correlation was found with progression free survival in newly-diagnosed grade II and grade III gliomas.

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