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Abstract #2955

Metabolic Characterization of Pre-Surgical Lower Grade Glioma Using Spectroscopic Imaging Optimized for 2-HG Detection

Marisa Lafontaine1, Adam Autry1, Llewellyn Jalbert1, Elizabeth Phillips1, Susan Chang2, and Yan Li1
1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Neurological Surgery, UCSF, San Francisco, CA, United States

2-HG optimized MR spectroscopic imaging showed 2HG was detected in 37 out of 40 IDH1+ patients. Although it was not significantly different between IDH+ and IDH- gliomas, significant correlation was found with progression free survival in newly-diagnosed grade II and grade III gliomas.

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