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Abstract #2957

A metabolomics approach for phenotyping IDH mutant gliomas using 1 and 2D NMR spectroscopy

Thomas Leather Leather1, Marie Phalen2, Khaja Sayed3, Nitika Rathi3, Michael Jenkinson4, Kumar Das4, and Harish Leather Poptani1
1University of Liverpool, Liverpool, United Kingdom, 2NMR Centre, University of Liverpool, Liverpool, United Kingdom, 3Neuropathology, Walton Centre NHS Foundation Trust, Liverpool, United Kingdom, 4Walton Centre NHS Foundation Trust, Liverpool, United Kingdom

The world health organisation has recognised mutations in the IDH1/2 gene as integral in diagnosis and prognostication of gliomas. The mutation facilitates production of the oncometabolite 2-hydroxygluarate (2-HG). The direct mechanisms behind the production and accumulation of 2-HG are well known, however we are yet to understand its effect on prognosis. Although the focus of in vivo studies has been on detection of the 2-HG peak, it is often impeded by spectral overcrowding. Here we used an NMR metabolomics approach to assess metabolome-wide alterations in the presence of the mutation to seek additionally detectable changes in metabolites in these tumours.

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