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Abstract #2958

Detection of 2-Hydroxyglutarate using JPRESS Magnetic Resonance Spectroscopy

Yan Zhang1 and Jun Shen1
1National Institute of Mental Health, Bethesda, MD, United States

A J-resolved PRESS (JPRESS) technique is proposed for detecting 2-hydroxyglutarate (2HG) in IDH mutant glioma patients at 3T. Spin density simulations and phantom experiments show that the spectral overlap between 2HG and glutamate at ~2.3 ppm is substantially reduced using the one-dimensional cross-sections at J = 0 and J = 7.5 Hz. These two cross-sections can be combined to quantify the 2HG concentration.

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