Abstract #2962

Quantification of 31P Human Brain spectra at 9.4T using ISIS and SPECIAL-semiLASER

Johanna Dorst¹, Loreen Ruhm¹, Nikolai Avdievich¹, Wolfgang Bogner², and Anke Henning^1,3

¹High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ²High-Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

For phosphorus single voxel MR spectroscopy, ISIS is often the method of choice, but it requires an 8 steps encoding scheme and post-acquisition signal combination which makes it prone to motion. Therefore, a SPECIAL-semiLASER sequence for ³¹P MRS was implemented in this study, which only needs two encoding steps for 3D localization. Spectra from the human brain acquired at 9.4T with both sequences are compared in terms of absolute SNR and SNR efficiency. Absolute SNR as well as SNR efficiency is lower for SPECIAL-semiLASER, but calculated concentrations are comparable.

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