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Abstract #2962

Quantification of 31P Human Brain spectra at 9.4T using ISIS and SPECIAL-semiLASER

Johanna Dorst1, Loreen Ruhm1, Nikolai Avdievich1, Wolfgang Bogner2, and Anke Henning1,3
1High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2High-Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 3Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

For phosphorus single voxel MR spectroscopy, ISIS is often the method of choice, but it requires an 8 steps encoding scheme and post-acquisition signal combination which makes it prone to motion. Therefore, a SPECIAL-semiLASER sequence for 31P MRS was implemented in this study, which only needs two encoding steps for 3D localization. Spectra from the human brain acquired at 9.4T with both sequences are compared in terms of absolute SNR and SNR efficiency. Absolute SNR as well as SNR efficiency is lower for SPECIAL-semiLASER, but calculated concentrations are comparable.

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