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Abstract #2961

31P MRSI of the human brain: do we need 7T to detect two Pi pools, UDPG signals and determine the NAD+/NADH ratio?

Arend Heerschap1, Tom H Peeters2, Andor Veltien2, and Tom W.J, Scheenen2
1Radiology, Radboud University Nijmegen Medical centre, Nijmegen, Netherlands, 2Radboud University Nijmegen Medical centre, Nijmegen, Netherlands

All resonances in human brain 31P MR spectra detectable at 7T and higher can also be detected at 3T provided that 1H decoupling, 1H-31P NOE and a 31P receive-array are used. This includes a alkaline peak for extracellular Pi and peaks assigned to UDPG. A NAD+/NADH redox state similar to that reported at 7T was observed. A comparison of measured T1 values with those reported at different field strengths and NOEs measured at 3 and 7T indicates that CSA is not dominant in 31P relaxation and hence there is no sensitivity benefit from shorter T1s at higher fields.

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