Abstract #2964

Differential modulation of the cerebral energy consumption by two different tDCS settings as measured by 31P MR spectroscopy

Chang-Hoon Choi¹, Elene Iordanishvili², Lea-Sophie Stollberg², Harshal Patel², N. Jon Shah^1,3,4,5, and Ferdinand Binkofski^1,2,4

¹INM-4, Forschungszentrum Juelich, Juelich, Germany, ²Department of Neurology, RWTH Aachen University Hospital, Aachen, Germany, ³INM-11, Forschungszentrum Juelich, Juelich, Germany, ⁴JARA-BRAIN-Translational Medicine, Aachen, Germany, ⁵Department of Neurology, RWTH Aachen University, Aachen, Germany

Abnormalities in energy regulation are thought to be linked to neurodegenerative and neuropsychiatric disorders. Here, we modulated the brain activity in M1 using sham/anodal tDCS with two different settings, and examined the effect on high-energy metabolites using in vivo ³¹P-MRS. PCr/Pi and ATP/Pi values showed a decreasing trend following the stimulation compared to the sham measurements and a statistically significant difference was shown between Pre-stimulation and Post-stimulations. However, differences in both PCr/Pi and ATP/Pi were not statistically significant when either a 10- or 20-minute stimulation protocol was applied, but longer stimulation showed a prolonged decrease in both PCr/Pi and ATP/Pi.

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