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Abstract #2964

Differential modulation of the cerebral energy consumption by two different tDCS settings as measured by 31P MR spectroscopy    

Chang-Hoon Choi1, Elene Iordanishvili2, Lea-Sophie Stollberg2, Harshal Patel2, N. Jon Shah1,3,4,5, and Ferdinand Binkofski1,2,4
1INM-4, Forschungszentrum Juelich, Juelich, Germany, 2Department of Neurology, RWTH Aachen University Hospital, Aachen, Germany, 3INM-11, Forschungszentrum Juelich, Juelich, Germany, 4JARA-BRAIN-Translational Medicine, Aachen, Germany, 5Department of Neurology, RWTH Aachen University, Aachen, Germany

Abnormalities in energy regulation are thought to be linked to neurodegenerative and neuropsychiatric disorders. Here, we modulated the brain activity in M1 using sham/anodal tDCS with two different settings, and examined the effect on high-energy metabolites using in vivo 31P-MRS. PCr/Pi and ATP/Pi values showed a decreasing trend following the stimulation compared to the sham measurements and a statistically significant difference was shown between Pre-stimulation and Post-stimulations. However, differences in both PCr/Pi and ATP/Pi were not statistically significant when either a 10- or 20-minute stimulation protocol was applied, but longer stimulation showed a prolonged decrease in both PCr/Pi and ATP/Pi.

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