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Abstract #2965

Volumetric mapping of the intracellular magnesium ion concentration in human calf muscles using 31P MRSI at 7 Tesla

Vanessa L. Franke1, Mark E. Ladd1, Peter Bachert1, and Andreas Korzowski1
1Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Intracellular free magnesium ion concentration [Mg2+free] is an important parameter in the regulation of the energy metabolism and can be assessed non-invasively by the use of 31P MRSI. The purpose of this study is to show that volumetric mapping of [Mg2+free] in the human calf muscle is possible at B0=7T with a voxel size of 1 ml. The [Mg2+free] maps of healthy volunteers showed local differences, presumably resulting from different muscle fiber compositions. Two different approaches employed for the calculation of [Mg2+free] yielded comparable maps but different absolute values, indicating the need for further investigation.

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