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Abstract #2966

Accelerating volumetric 31P MRSI of the human calf muscle at 7 Tesla: can low-rank denoising filters replace the need for signal averaging?

Andreas Korzowski1, Johannes Breitling1, Vanessa L. Franke1, Mark E. Ladd1, and Peter Bachert1
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Volumetric 31P MRSI in the human calf muscle at 7T in principle enables acquisitions with high spatial resolution, but may require signal averaging to improve signal-to-noise ratios of low-concentrated metabolites. To minimize the acquisition duration of volumetric 31P MRSI, in this study we demonstrate that the acquisition of signal averages can be reliably substituted by application of low-rank denoising filters without the introduction of a quantification bias. This allows acquisition of 31P MRSI data with 1 ml voxels in measurement durations of only 14 minutes that have the same quality as if acquired in 56 minutes with signal averaging.

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