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Abstract #2970

A Perfusate Comparison for Ex-Vivo Lung Preservation: Using 31P MRS to Assess Cold Perfadex and Modified Krebs–Henseleit Buffer

Jonathan Snow1, Mehrdad Pourfathi1, Sarmad Siddiqui1, Ian Duncan1, Harrilla Profka1, Federico Sertic1,2, Stephen J Kadlecek1, Gabriel Unger1, Hooman Hamedani1,3, Yi Xin1,3, Luis Loza1, Faraz Amzajerdian 1,3, Tahmina Achekzai1, Kai Ruppert1, Ryan Baron1, Yiwen Qian1,3, Michael Rosalino1, Maurizio Cereda1,4, Shampa Chatterjee5, and Rahim R. Rizi1
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Surgery, University of Pennsylvania, Philadelphia, PA, United States, 3Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 4Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States, 5Physiology, University of Pennsylvania, Philadelphia, PA, United States

Ex-vivo lung perfusion (EVLP) is a procedure used in clinical care to support lung viability during transplantation. Here, we used magnetic resonance spectroscopy (MRS) to monitor and compare the energy status of ex-vivo rat lungs flushed and stored in cold Perfadex or perfused with a modified warm Krebs-Henseleit buffer. The results demonstrate decreasing energy status over the course of the 3hr experiment under both conditions, with a slightly lower rate of decline in lung viability using cold Perfadex.

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