Abstract #2970

A Perfusate Comparison for Ex-Vivo Lung Preservation: Using 31P MRS to Assess Cold Perfadex and Modified Krebs–Henseleit Buffer

Jonathan Snow¹, Mehrdad Pourfathi¹, Sarmad Siddiqui¹, Ian Duncan¹, Harrilla Profka¹, Federico Sertic^1,2, Stephen J Kadlecek¹, Gabriel Unger¹, Hooman Hamedani^1,3, Yi Xin^1,3, Luis Loza¹, Faraz Amzajerdian ^1,3, Tahmina Achekzai¹, Kai Ruppert¹, Ryan Baron¹, Yiwen Qian^1,3, Michael Rosalino¹, Maurizio Cereda^1,4, Shampa Chatterjee⁵, and Rahim R. Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Surgery, University of Pennsylvania, Philadelphia, PA, United States, ³Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ⁴Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States, ⁵Physiology, University of Pennsylvania, Philadelphia, PA, United States

Ex-vivo lung perfusion (EVLP) is a procedure used in clinical care to support lung viability during transplantation. Here, we used magnetic resonance spectroscopy (MRS) to monitor and compare the energy status of ex-vivo rat lungs flushed and stored in cold Perfadex or perfused with a modified warm Krebs-Henseleit buffer. The results demonstrate decreasing energy status over the course of the 3hr experiment under both conditions, with a slightly lower rate of decline in lung viability using cold Perfadex.

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