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Abstract #2971

Neurodegenerative changes in the brain of Alzheimer’s mice investigated by high-field 1H-31P MRS and segmentation on high-resolution MRI

Chi-Hyeon Yoo1,2, Hyeon-Man Baek2, and Bo-Young Choe1
1The Catholic University of Korea, Seoul, Republic of Korea, 2Gacheon University, Incheon, Republic of Korea

The aim of this study was to investigate morphological and metabolic changes in the brain of model mice with AD by using combined 1H-31P MRS and 3D T2 MRI in an integrated way. To investigate the AD-related metabolic changes, mean concentrations and /PCr relative ratios were compared between the groups for all major metabolites. In addition, a volumetric analysis was conducted on the volume of hippocampus, entorhinal cortex, and PFC between the groups. The AD-related changes in brain can be investigated by high-field and short-TE 1H MRS and high-resolution T2-weighted MRI in conjugate with the altas-based automatic brain segmentation.

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