Cerebral creatine is affected by many CNS disorders. Combining phosphorus and proton MRS to evaluate both phosphocreatine and creatine may provide important insight into brain energetics associated with abnormal creatine levels as the creatine kinase reaction is strongly coupled to energy metabolism in the CNS. Here we show that the PCr to total phosphate ratio is highly immune to T1 saturation effect. By combining phosphorus and proton MRS of healthy subjects we demonstrate that it is feasible to characterize creatine phosphorylation with high immunity to T1 saturation.
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