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Abstract #2974

Fast 31P-MRSI of the brain at 3T using concentric ring (CONCEPT) MRSI

William T Clarke1, Lukas Hingerl2, Wolfgang Bogner2, Christopher T Rodgers3,4, and Ladislav Valkovic4,5
1Wellcome Centre for Integrative Neuroimaging, NDCN, University of Oxford, Oxford, United Kingdom, 2High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 3Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, 4Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 5Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia

A density-weighted concentric ring trajectory MRSI sequence is created for 31P-MRSI of the human brain at 3T. The sequence is assessed in three subjects at five different acquisition times (7:28 – 1:07 minutes) and compared against resolution and time-matched 3D cartesian CSI sequences. The proposed CONCEPT MRSI sequences robustly measure 3D localised PCr/ATP ratios of the human brain 1.5 times faster than the minimum possible with CSI at a matched repetition time. This opens the possibility of fast dynamic measurements of PCr/ATP in whole human cerebrum at 3T.

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