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Abstract #2975

Therapeutic Efficacy of Stem Cell Donors for Stroke as Determined by 23Na MRI and 1H MRS at 21.1 T

Shannon Helsper1,2, Xuegang Yuan1,2, F. Andrew Bagdasarian1,2, and Samuel Colles Grant1,2
1National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 2Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, United States

This study evaluates the therapeutic efficacy of human mesenchymal stem cells (hMSC) from different donors applied to an ischemic rat model. Biochemical markers of tissue recovery were measured longitudinally over 21 d using sodium chemical shift imaging, relaxation enhanced MR spectroscopy, and T2-weighted proton imaging at 21.1 T. Ultra-high field provided increased sensitivity, enabling insight into ionic and metabolic regulation while demonstrating differential recovery based on donor characteristics evident only after extended culture. With trophic and immunomodulation effects, hMSC hold promise for cell-based stroke therapy, but donor variance must be evaluated for translation. MR metrics classify donor quality and effectiveness.

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