Abstract #2977

Corrections of cardiac 23Na-MRI measurements in mice with an in-house build surface coil at 7T

Martin Christa¹, Ibrahim A. Elabyad², Wolfgang Rudolf Bauer¹, and Maxim Terekhov²

¹Comprehensive Heart Failure Center (CHFC), Department of Internal Medicine I, University Hospital Wuerzburg, Wuerzburg, Germany, ²Comprehensive Heart Failure Center (CHFC), Chair of Cellular and Molecular Imaging, University Hospital Wuerzburg, Wuerzburg, Germany

With higher field strength and, thus, better SNR available, 23Na-MRI is becoming increasingly popular in (pre-) clinical studies. Improving accuracy and repeatability will help to translate 23Na-MRI into routine. Therefore, we investigated the effect of respiratory and cardiac gating, as well as the influence of B1-field correction on cardiac total sodium quantification with a 2D radial UTE sequence in mice using a surface coil at 7T. We found that ungated and uncorrected measurements overestimate cardiac sodium concentration. Combined respiratory and cardiac gating and B1-field correction significantly decreased the measured cardiac tissue sodium concentration (-40.6%).

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