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Abstract #2977

Corrections of cardiac 23Na-MRI measurements in mice with an in-house build surface coil at 7T

Martin Christa1, Ibrahim A. Elabyad2, Wolfgang Rudolf Bauer1, and Maxim Terekhov2
1Comprehensive Heart Failure Center (CHFC), Department of Internal Medicine I, University Hospital Wuerzburg, Wuerzburg, Germany, 2Comprehensive Heart Failure Center (CHFC), Chair of Cellular and Molecular Imaging, University Hospital Wuerzburg, Wuerzburg, Germany

With higher field strength and, thus, better SNR available, 23Na-MRI is becoming increasingly popular in (pre-) clinical studies. Improving accuracy and repeatability will help to translate 23Na-MRI into routine. Therefore, we investigated the effect of respiratory and cardiac gating, as well as the influence of B1-field correction on cardiac total sodium quantification with a 2D radial UTE sequence in mice using a surface coil at 7T. We found that ungated and uncorrected measurements overestimate cardiac sodium concentration. Combined respiratory and cardiac gating and B1-field correction significantly decreased the measured cardiac tissue sodium concentration (-40.6%).

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