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Abstract #2983

Non-Invasive Dynamic Assessment of Heart Energy Metabolisms using in vivo Deuterium MRS Imaging and Close Chest Model

Tao Wang1,2, Xiao-Hong Zhu1, Byeong-Yeul Lee1, Wei Zhu1,2, Hannes M Wiesner1, Yi Zhang1, and Wei Chen1
1Center for Magnetic Resonance Research, Radiology, University of Minnesota, Minneapolis, MN, United States, 2Medical Physics, Radiation Oncology, University of Minnesota, Minneapolis, MN, United States

Continuation from our previous open-chest rat heart project to exploit the in-vivo deuterium (2H) MRS (DMRS) or imaging (DMRSI) methods for dynamic measurement of the myocardial energy metabolism in rat heart at 16.4 T, we further tested its sensitivity and feasibility in response to cardiac glucose metabolism as compared with acetate using a non-invasive method on close-chest rats by using a 1H/2H dual-frequency surface coil. This work demonstrates that both fatty acids and glucose are the main sources of fuel for cardiac activities with a preference for fatty acids.

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