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Abstract #2982

Quantitative Human Cardiac 39K MRI at 7T: What is feasible? 

Johanna Lott1,2, Tanja Platt1, Sebastian C Niesporek1, Daniel Wenz3, Peter Bachert1,2, Mark E Ladd1,2,4, Thoralf Niendorf5,6, and Armin M Nagel1,7,8
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, 3Center for Biomedical Imaging - Animal Imaging and Technology (CIBM-AIT), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4Faculty of Medicine, University of Heidelberg, Heidelberg, Germany, 5Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 6MRI. TOOLS GmbH, Berlin, Germany, 7Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 8Institute of Medical Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany

Monitoring the viability of myocardial tissue is of prognostic value after an ischemic event1-3. Ultrahigh fields (B0≥7T) facilitates cardiac 39K MRI. However, short relaxation times, low signal-to-noise ratio, and low spatial resolution render the quantitative determination of the myocardial tissue potassium concentration (mTPC) challenging. We analyze the feasibility of quantitative cardiac 39K MRI at 7T with simulations. For realistic noise conditions the mTPC can be determined with a deviation of 14% from the ground truth by applying a partial volume correction. Quantitative cardiac 39K MRI would further benefit e.g. from higher magnetic field strengths (B0>7T) or iterative reconstruction techniques.

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