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Abstract #2987

Towards structure and metabolism of glycogen C1-C6 by 13C MRS at 7T using broadband 1H decoupling and low-power NOE by means of bi-level WALTZ cycles

Eulalia Serés Roig1 and Rolf Gruetter1,2,3
1Laboratory of Functional and Metabolic Imaging (LIFMET) - Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 2Centre d'Imagerie BioMédicale - Animal and Imaging Technology (CIBM-AIT) - Ecole Polytechnique de Lausanne (EPFL), Lausanne, Switzerland, 3Department of Radiology, Universities of Lausanne (UNIL) and Geneva (UNIGE), Lausanne, Switzerland

Glycogen metabolism is essential for glucose homeostasis in humans and may be disrupted in a variety of diseases. Largely neglected due to its low concentration, yet brain glycogen plays an active role in brain energy metabolism, such as during hypo-glycemia. Carbon-13 Magnetic Resonance Spectroscopy (13C MRS) allows the non-invasive detection of glycogen in vivo, while is typically done via the C1 carbon signal. In this study, we explore the potential of 13C MRS at 7T using uniform 13C excitation and bi-level broadband 1H-decoupling towards simultaneous detection of glycogen C1-C6 in vivo in human muscle, as a step towards brain studies.

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