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Abstract #2992

Detection of Human Muscle Glycogen by Natural Abundance Carbon-13 MRS at 7 T with Short Duration Proton Decoupling

Li An1, Shizhe Li1, Kalpana Manthiram2, Jyoti Singh Tomar1, Hirotsugu Oda2, Carlos R Ferreira2, and Jun Shen1
1National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States, 2National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States

In this work, a continuous wave (CW) proton decoupling with a short duration of 15 ms was used to detect natural abundance 13C glycogen C1 signals in the human calf at 7 T. This short duration CW proton decoupling dramatically reduced RF power deposition, which allowed the TR to be shortened to 310 ms and additional NOE pulses to be used to ensure optimal SNR performance. The reconstructed glycogen spectra and the peak area ratio between decoupled and non-decoupled glycogen C1 resonances demonstrated that adequate proton decoupling was achieved.

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