Abstract #2992

Detection of Human Muscle Glycogen by Natural Abundance Carbon-13 MRS at 7 T with Short Duration Proton Decoupling

Li An¹, Shizhe Li¹, Kalpana Manthiram², Jyoti Singh Tomar¹, Hirotsugu Oda², Carlos R Ferreira², and Jun Shen¹

¹National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States, ²National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States

In this work, a continuous wave (CW) proton decoupling with a short duration of 15 ms was used to detect natural abundance ¹³C glycogen C1 signals in the human calf at 7 T. This short duration CW proton decoupling dramatically reduced RF power deposition, which allowed the TR to be shortened to 310 ms and additional NOE pulses to be used to ensure optimal SNR performance. The reconstructed glycogen spectra and the peak area ratio between decoupled and non-decoupled glycogen C1 resonances demonstrated that adequate proton decoupling was achieved.

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