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Abstract #2993

tcaCALC: MATLAB Software for Quantitative Analysis of 13C Metabolic Isotopic Tracer Experiments

Jeffry R. Alger1,2,3, Gaurav Sharma1, A. Dean Sherry1,4, and Craig R. Malloy1,5
1Advanced Imaging Research Center, University of Texas, Southwestern Medical Center, Dallas, TX, United States, 2Neurology, University of California, Los Angeles, Los Angeles, CA, United States, 3NeuroSpectroScopics LLC, Sherman Oaks, CA, United States, 4Department of Chemistry, Universiy of Texas at Dallas, Richardson, TX, United States, 5Department of Internal Medicine, University of Texas-Southwestern Medical Center, Dallas, TX, United States

tcaCALC has been developed as a MATLAB tool that facilitates the quantitative analysis of metabolic tracing experiments that use 13C enriched tracers. The most recent version of tcaCALC facilitates analysis by incorporating spectral fitting of J-coupled 13C NMR multiplets and modeling complex metabolic situations in which specific metabolic fluxes may be active or inactive. The MATLAB source code and a compiled version are available for sharing to interested research teams.

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