Abstract #2993

tcaCALC: MATLAB Software for Quantitative Analysis of 13C Metabolic Isotopic Tracer Experiments

Jeffry R. Alger^1,2,3, Gaurav Sharma¹, A. Dean Sherry^1,4, and Craig R. Malloy^1,5

¹Advanced Imaging Research Center, University of Texas, Southwestern Medical Center, Dallas, TX, United States, ²Neurology, University of California, Los Angeles, Los Angeles, CA, United States, ³NeuroSpectroScopics LLC, Sherman Oaks, CA, United States, ⁴Department of Chemistry, Universiy of Texas at Dallas, Richardson, TX, United States, ⁵Department of Internal Medicine, University of Texas-Southwestern Medical Center, Dallas, TX, United States

tcaCALC has been developed as a MATLAB tool that facilitates the quantitative analysis of metabolic tracing experiments that use ¹³C enriched tracers. The most recent version of tcaCALC facilitates analysis by incorporating spectral fitting of J-coupled ¹³C NMR multiplets and modeling complex metabolic situations in which specific metabolic fluxes may be active or inactive. The MATLAB source code and a compiled version are available for sharing to interested research teams.

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