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Abstract #2996

19F MRS Detection of Tau Aggregates Using Lansoprazole in an Ex Vivo Rat Model of Alzheimer’s Disease

Sarah K Yeo1, Yurii Shepelytskyi2, Vira Grynko2, Francis T Hane3,4, Tao Li3, and Mitchell S Albert3,4,5
1Biology, Lakehead University, Thunder Bay, ON, Canada, 2Chemistry and Materials Science, Lakehead University, Thunder Bay, ON, Canada, 3Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, 4Chemistry, Lakehead University, Thunder Bay, ON, Canada, 5Northern Ontario School of Medicine, Thunder Bay, ON, Canada

Neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein are pathological characteristics of Alzheimer’s Disease (AD). Thus, the use of biosensors that bind to NFTs are beneficial for in vivo detection of tauopathy. This study evaluates the use of Lansoprazole (LSZ) as an indicator of NFTs in AD brains. 19F MRS of AD and control brains with LSZ was acquired using a 3.0T clinical MRI scanner. We demonstrate that the 19F signal from LSZ interacts with NFTs in a rat model of AD. This shows potential in using LSZ to distinguish between AD and healthy brains with a clinical 3.0T scanner.

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