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Abstract #3000

Effects of Anaerobic Exercise in Skeletal Muscle Measured by Hyperpolarized [1-13C]Pyruvate in Humans

Jae Mo Park1,2,3, Edward P Hackett2, Crystal E Harrison2, Galen D Reed4, Avneesh Chhabra1, and Craig R Malloy2
1Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Electrical Engineering, University of Texas Dallas, Richardson, TX, United States, 4GE Healthcare, GE Healthcare, Dallas, TX, United States

Direct studies of lactate and pyruvate metabolism by biopsy or vascular cannulation during or after exercise is undesirable. The fraction of pyruvate that is oxidized to CO2 vs. reduced to lactate in skeletal muscle was studied in healthy human subjects using hyperpolarized [1-13C]pyruvate at rest and after toe-lift exercise. There was a 2.5x fold increase in lactate production but negligible oxidation of pyruvate in the Krebs cycle. Hyperpolarization methods offer a novel approach to studying lactate and pyruvate metabolism in human skeletal muscle that is readily acceptable to subjects.

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