Abstract #3007

Imaging the metabolic evolution of glioblastoma throughout tumor development, regression and relapse

Travis Salzillo^1,2, Joy Gumin³, Jaehyuk Lee¹, Frederick Lang³, and Pratip Bhattacharya¹

¹Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, United States, ²The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, United States, ³Neurosurgery, MD Anderson Cancer Center, Houston, TX, United States

Glioblastoma metabolism was interrogated at several time-points during tumor development, regression following radiotherapy, and eventual recurrence. Pyruvate-to-lactate conversion measured with hyperpolarized magnetic resonance imaging (MRI) was compared with tumor volume measured with conventional MRI to determine which was more sensitive at detecting tumor progression. These results were correlated with ex vivo measurements of global metabolism using nuclear magnetic resonance spectroscopy as well as the expression of relevant proteins such as LDH-A, ALT, HIF-1a, MCT1, and MCT4 using immunohistochemistry. A comprehensive analysis of metabolic trajectories throughout the entirety of tumor evolution will be presented.

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