Abstract #3009

Association of prostate cancer androgen sensitivity with dynamic metabolic imaging of hyperpolarized [1-13C]pyruvate

Aditya Jhajharia¹, Dexue Fu², Maninder Singh¹, Shu Wang², Ian Qian², Aidan Kennedy², Mohummad M. Siddiqui^2,3,4, and Dirk Mayer^1,3

¹Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ²Department of Surgery, Division of Urology, Baltimore, MD, United States, ³Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, United States, ⁴The Veterans Health Administration Research and Development Service, Baltimore, MD, United States

Metabolic signatures of androgen-dependent (LNCaP) and androgen-independent (CSS90) prostate tumors were investigated using hyperpolarized [1-¹³C]pyruvate imaging. Higher pyruvate-to-lactate conversion in CSS90 were confirmed by higher glycolysis in CSS90 measured by extracellular acidification rate of the tumor slices. Treatment with MDV3100 lead to higher oxidative phosphorylation measured by oxygen consumption rate. Initial in vivo experiments suggested a reduced pyruvate-to-lactate conversion in LNCaP tumors after treatment, potentially a marker for positive response to therapy. These findings demonstrated that conversion of hyperpolarized pyruvate to lactate is a useful biomarker to both characterize tumor androgen sensitivity and potentially to evaluate response to therapy.

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