Meeting Banner
Abstract #3009

Association of prostate cancer androgen sensitivity with dynamic metabolic imaging of hyperpolarized [1-13C]pyruvate  

Aditya Jhajharia1, Dexue Fu2, Maninder Singh1, Shu Wang2, Ian Qian2, Aidan Kennedy2, Mohummad M. Siddiqui2,3,4, and Dirk Mayer1,3
1Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2Department of Surgery, Division of Urology, Baltimore, MD, United States, 3Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, United States, 4The Veterans Health Administration Research and Development Service, Baltimore, MD, United States

Metabolic signatures of androgen-dependent (LNCaP) and androgen-independent (CSS90) prostate tumors were investigated using hyperpolarized [1-13C]pyruvate imaging. Higher pyruvate-to-lactate conversion in CSS90 were confirmed by higher glycolysis in CSS90 measured by extracellular acidification rate of the tumor slices. Treatment with MDV3100 lead to higher oxidative phosphorylation measured by oxygen consumption rate. Initial in vivo experiments suggested a reduced pyruvate-to-lactate conversion in LNCaP tumors after treatment, potentially a marker for positive response to therapy. These findings demonstrated that conversion of hyperpolarized pyruvate to lactate is a useful biomarker to both characterize tumor androgen sensitivity and potentially to evaluate response to therapy.

This abstract and the presentation materials are available to members only; a login is required.

Join Here