Our previous study in a rat lung transplant model using HP [1-13C]-pyruvate MRI demonstrated that an increased lactate-to-pyruvate ratio (LtP) precedes lung rejection. However, most lungs in a clinical setting are obtained after donor brain death (DBD), which is associated with increased ischemia-reperfusion injury and risk of acute lung rejection. In this study, we transplanted DBD-lungs into syngeneic rats and compared the metabolism of DBD-donor lungs to our previous normotensive-donor model. The LtP of the DBD-graft is approximately two-fold higher than that of the other lungs, suggesting that HP [1-13C]-pyruvate imaging can be used to identify grafts with ischemia-reperfusion injury.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords