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Abstract #3011

Hyperpolarized 13C MRI Improves Sensivity of Pulmonary Inflammation Detection in an Acid Aspiration Rat Model of ARDS

Mehrdad Pourfathi1, Hooman Hamedani1,2, Michael Rosalino1, Stephen J Kadlecek1, Yi Xin1,2, Ian Duncan1, Maurizio Cereda1,3, Sarmad Siddiqui1, Harrilla Profka1, Luis Loza1, Faraz Amzajerdian 1,2, Tahmina Achekzai1, Kai Ruppert1, Federico Sertic1,4, Ryan Baron1, Jon Snow1, Yiwen Qian1,2, Gabriel Unger1, Shampa Chatterjee5, and Rahim R. Rizi1
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 3Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States, 4Surgery, University of Pennsylvania, Philadelphia, PA, United States, 5Physiology, University of Pennsylvania, Philadelphia, PA, United States

Elevated Hyperpolarized (HP) lactate-to-pyruvate ratio has previously been linked to pulmonary inflammation. In this study, we used a logistic regression model to assess the added value of HP lactate-to-pyruvate ratio as a predictive marker of lung inflammation. Our data suggests, the combination of metabolic and functional information improves both sensitivity of detecting lung inflammation than functional information alone.

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