Abstract #3011

Hyperpolarized 13C MRI Improves Sensivity of Pulmonary Inflammation Detection in an Acid Aspiration Rat Model of ARDS

Mehrdad Pourfathi¹, Hooman Hamedani^1,2, Michael Rosalino¹, Stephen J Kadlecek¹, Yi Xin^1,2, Ian Duncan¹, Maurizio Cereda^1,3, Sarmad Siddiqui¹, Harrilla Profka¹, Luis Loza¹, Faraz Amzajerdian ^1,2, Tahmina Achekzai¹, Kai Ruppert¹, Federico Sertic^1,4, Ryan Baron¹, Jon Snow¹, Yiwen Qian^1,2, Gabriel Unger¹, Shampa Chatterjee⁵, and Rahim R. Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ³Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States, ⁴Surgery, University of Pennsylvania, Philadelphia, PA, United States, ⁵Physiology, University of Pennsylvania, Philadelphia, PA, United States

Elevated Hyperpolarized (HP) lactate-to-pyruvate ratio has previously been linked to pulmonary inflammation. In this study, we used a logistic regression model to assess the added value of HP lactate-to-pyruvate ratio as a predictive marker of lung inflammation. Our data suggests, the combination of metabolic and functional information improves both sensitivity of detecting lung inflammation than functional information alone.

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