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Abstract #3012

Safety, Tolerability and Reproducibility of HP13C-MRI in Normal, Healthy Human Subjects

Robert Bok1, Hsin-Yu Chen1, Jeremy Gordon1, Adam Autry1, Shuyu Tang1, Brian Chung1, James Slater1, Peder E.Z. Larson1, Yan Li1, Mark van Criekinge1, Priscilla Chan1, Romelyn Delos Santos1, Evelyn Escobar1, Kimberly Okamoto1, Mary Frost1, John Kurhanewicz1, and Daniel B. Vigneron1
1Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

HP 13C-MRI with 13C-Pyruvate was performed in normal, healthy volunteers over four major body regions and organs, including head/brain, chest/heart, abdomen/liver, and pelvis/kidneys. Many individuals received multiple HP 13C injections and a variety of acquisition sequence. Pyruvate-to-lactate conversion rate measurements were reproducible across days and coil configurations. All injections and imaging were very well tolerated with no adverse effects observed in over 70 scans.

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