Abstract #3012

Safety, Tolerability and Reproducibility of HP13C-MRI in Normal, Healthy Human Subjects

Robert Bok¹, Hsin-Yu Chen¹, Jeremy Gordon¹, Adam Autry¹, Shuyu Tang¹, Brian Chung¹, James Slater¹, Peder E.Z. Larson¹, Yan Li¹, Mark van Criekinge¹, Priscilla Chan¹, Romelyn Delos Santos¹, Evelyn Escobar¹, Kimberly Okamoto¹, Mary Frost¹, John Kurhanewicz¹, and Daniel B. Vigneron¹

¹Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

HP ¹³C-MRI with ¹³C-Pyruvate was performed in normal, healthy volunteers over four major body regions and organs, including head/brain, chest/heart, abdomen/liver, and pelvis/kidneys. Many individuals received multiple HP 13C injections and a variety of acquisition sequence. Pyruvate-to-lactate conversion rate measurements were reproducible across days and coil configurations. All injections and imaging were very well tolerated with no adverse effects observed in over 70 scans.

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