Dynamic metabolic imaging was used to investigate the origin of the lactate signal in rat brain after injection with hyperpolarized (HP) [1-13C] pyruvate. In order to suppress signal with vascular components, we applied a bipolar gradient pulse with different duration prior to data acquisition. The presented results provide further evidence that transport of HP pyruvate into the brain and its subsequent conversion to lactate is limited by blood-brain barrier transport and that the majority of the HP lactate observed in brain was indeed produced there.
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