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Abstract #3014

Distinguishing metabolic signals of liver tumors from surrounding liver cells using hyperpolarized 13C MRI and Gadoxetate

Shubhangi Agarwal1, Jeremy Gordon1, Natalie Korn1, Robert A Bok1, Cornelius von Morze2, Daniel B Vigneron1, John Kurhanewicz1, and Michael Ohliger1,3
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Biomedical Magnetic Resonance Laboratory, Washington University School of Medicine, St. Louis, MO, United States, 3Liver Center, University of California, San Francisco, San Francisco, CA, United States

Hyperpolarized (HP) 13C MRI is a promising technique that can assess the metabolic pathways in a variety of tumors non-invasively and in real time. In this study, we show the ability of a gadolinium-based contrast agent (gadoxetate) to selectively suppress the HP metabolic signal arising from normal hepatocytes by altering the relaxation rates of metabolites 13C pyruvate and 13C lactate in order to evaluate the metabolic profile of tumors within the liver.

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