Abstract #3018

Selective hyperpolarized 13C metabolites suppression from a liver-specific gadolinium contrast agent using an NMR-compatible bioreactor

Ting Sun^1,2, Renuka Sriram¹, Kathy Giacomini¹, James Chien¹, Sook Wah Yee¹, Shubhangi Agarwal¹, Joao Piraquive Agudelo¹, Cornelius Von Morze³, John Kurhanewicz¹, Huadan Xue², and Michael Ohliger¹

¹University of California, San Francisco, San Francisco, San Francisco, CA, United States, ²Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, ³Washington University, Seattle, WA, United States

This study demonstrated that hyperpolarized ¹³C metabolic signals arising from intracellular and extracellular ¹³C metabolites can be selectively suppressed by the intracellular liver-specific gadolinium contrast agent. This data further elucidates how targeted relaxation agents affect observed hyperpolarized ¹³C signals, expanding the way these agents can be used to distinguish between specific cell types in vivo.

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