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Abstract #3018

Selective hyperpolarized 13C metabolites suppression from a liver-specific gadolinium contrast agent using an NMR-compatible bioreactor

Ting Sun1,2, Renuka Sriram1, Kathy Giacomini1, James Chien1, Sook Wah Yee1, Shubhangi Agarwal1, Joao Piraquive Agudelo1, Cornelius Von Morze3, John Kurhanewicz1, Huadan Xue2, and Michael Ohliger1
1University of California, San Francisco, San Francisco, San Francisco, CA, United States, 2Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, 3Washington University, Seattle, WA, United States

This study demonstrated that hyperpolarized 13C metabolic signals arising from intracellular and extracellular 13C metabolites can be selectively suppressed by the intracellular liver-specific gadolinium contrast agent. This data further elucidates how targeted relaxation agents affect observed hyperpolarized 13C signals, expanding the way these agents can be used to distinguish between specific cell types in vivo.

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