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Abstract #3022

Imaging a tumor hallmark: hyperpolarized [U-13C, U-2H]-glucose and [1-13C]-alanine non-invasively monitor TERT expression in gliomas in vivo

Pavithra Viswanath1, Georgios Batsios1, Anne Marie Gillespie1, Peng Cao1, Peder E Z Larson1, Russell O Pieper2, and Sabrina M Ronen1
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Neurological Surgery, University of California San Francisco, San Francisco, CA, United States

Telomerase reverse transcriptase (TERT) expression is a fundamental hallmark of tumor proliferation, including in low-grade oligodendrogliomas. Inhibiting TERT expression is also a therapeutic strategy for gliomas. In this study, we show, for the first time, that metabolism of hyperpolarized [U-13C,U-2H]-glucose to 6-phosphogluconate via the pentose phosphate pathway and hyperpolarized [1-13C]-alanine flux to lactate can serve to non-invasively detect TERT expression in orthotopic low-grade oligodendrogliomas in vivo. Our imaging biomarkers will allow non-invasive, longitudinal detection of a molecular hallmark of tumor proliferation and have the potential to enhance imaging of glioma burden and response to emerging TERT therapies in the clinic.

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