Abstract #3028

ROKET: a Robust Keto Enol Tautomerisation phantom for multi-site, multi-vendor hyperpolarized 13C studies

Liam A J Young^1,2, Jack JJJ Miller^1,3, Ladislav Valkovic^1,4, Esben SS Hansen⁵, Mary A McLean^6,7, Ferdia A Gallagher⁷, Christoffer Laustsen⁵, Damian J Tyler^1,3, Christopher T Rodgers^1,2, and Justin YC Lau^1,3

¹Oxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, Oxford, United Kingdom, ²Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, ³Department of Anatomy and Physiology, University of Oxford, Oxford, United Kingdom, ⁴Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, ⁵Department of Clinical Medicine, the MR Research Centre, Aarhus University, Aarhus N, Denmark, ⁶CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, ⁷Department of Radiology, University of Cambridge, Cambridge, United Kingdom

As dissolution dynamic nuclear polarization (d-DNP) hyperpolarised ¹³C magnetic resonance imaging progresses towards multi-centre clinical trials, a reproducible, scalable in vitro testing platform is required that allows quality assurance, multi-centre validation, and further technical development. We present a method to exploit the inherent pH dependence of the hydrate-to-keto ratio of pyruvic acid to generate a simple, inexpensive, and reproducible non-enzymatic dynamic phantom to address this need. The method was validated at three different sites with a variety of hardware produced by different vendors.

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