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Abstract #3028

ROKET: a Robust Keto Enol Tautomerisation phantom for multi-site, multi-vendor hyperpolarized 13C studies

Liam A J Young1,2, Jack JJJ Miller1,3, Ladislav Valkovic1,4, Esben SS Hansen5, Mary A McLean6,7, Ferdia A Gallagher7, Christoffer Laustsen5, Damian J Tyler1,3, Christopher T Rodgers1,2, and Justin YC Lau1,3
1Oxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, Oxford, United Kingdom, 2Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, 3Department of Anatomy and Physiology, University of Oxford, Oxford, United Kingdom, 4Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, 5Department of Clinical Medicine, the MR Research Centre, Aarhus University, Aarhus N, Denmark, 6CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 7Department of Radiology, University of Cambridge, Cambridge, United Kingdom

As dissolution dynamic nuclear polarization (d-DNP) hyperpolarised 13C magnetic resonance imaging progresses towards multi-centre clinical trials, a reproducible, scalable in vitro testing platform is required that allows quality assurance, multi-centre validation, and further technical development. We present a method to exploit the inherent pH dependence of the hydrate-to-keto ratio of pyruvic acid to generate a simple, inexpensive, and reproducible non-enzymatic dynamic phantom to address this need. The method was validated at three different sites with a variety of hardware produced by different vendors.

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