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Abstract #3027

Fast 3D hyperpolarized 13C metabolic MRI at 7 T using spectrally selective bSSFP

Jason Graham Skinner1, Geoffrey Topping1, Irina Heid2, Maximilian Aigner1, Martin Grashei1, Christian Hundshammer1, Lukas Kritzner2, Frits Hendrik Anton van Heijster1, Tim Wartewig3,4, Erik Hameister3,4, J├╝rgen Ruland3,4,5,6, Rickmer Braren2, and Franz Schilling1
1Nuclear Medicine, Klinikum rechts der Isar, The Technical University of Munich, Munich, Germany, 2Institute of Radiology, Klinikum rechts der Isar, The Technical University of Munich, Munich, Germany, 3Institute for Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, The Technical University of Munich, Munich, Germany, 4TranslaTUM, Center for Translational Cancer Research, The Technical University of Munich, Munich, Germany, 5German Cancer Consortium (DKTK), Heidelberg, Germany, 6German Center for Infection Research (DZIF), Munich, Germany

A fast, spectrally selective 3D bSSFP sequence was developed for preclinical metabolic imaging of hyperpolarized 13C agents at 7 T. High spatiotemporal resolution 3D images of metabolism were produced in healthy mice and in two endogenous models of cancer: pancreatic ductal adenocarcinoma (PDAC) and T-cell lymphoma. Using 900 Hz FHWM pulses, 1.75 mm3 isotropic whole-body images were obtained with a scantime of 1.212 s per image. A significant difference between 3D bSSFP derived AUC ratios in healthy and high-glycolytic-phenotype T-cell lymphoma mice was found, and AUC ratios correlated with PET measurements. Potential tumour heterogeneity was detected in PDAC mice.

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