Abstract #3032

Novel Real-time Hyperpolarized 13C Metabolic Tracer Probes γ-Glutamyl Transferase Activities in vivo Tumor Xenografts

Tomohiro Seki¹, Kazutoshi Yamamoto², Nobu Oshima¹, Marino Itoda³, Yohei Kondo³, Yutaro Saito³, Yoichi Takakusagi⁴, Shun Kishimoto¹, Jeffrey R Brender¹, Ronja M Malinowski⁵, Jan Henrik Ardenkjær-Larsen⁶, Hiroshi Nonaka³, Murali C Krishna¹, and Shinsuke Sando³

¹National Institutes of Health, Bethesda, MD, United States, ²National Cancer Institute, National Institutes of Health, Bethesda, MD, United States, ³University of Tokyo, Bunkyo ku, Japan, ⁴Quantum Medical Science, Chiba, Japan, ⁵Technical University of Denmark, Lyngby, Denmark, ⁶Department of Electrical Engineering, Technical University of Denmark, Lyngby, Denmark

It is well known that dysregulation of γ-glutamyl transferase (GGT) activities in malignant cells leads to more aggressive phenotypes by producing reactive oxygen species. GGT is important for glutathione homeostasis, and has also been used as a diagnostic marker for various pathologies in the liver, biliary system, and pancreas. Here, for the first time, a novel hyperpolarized 13C probe, γ-Glu-[1-¹³C]Gly, was demonstrated in in vivo tumor xenografts, including human pancreatic ductal adenocarcinoma and ovarian adenocarcinoma, to detect real-time γ-glutamyl transferase activities as a prospective biomarker for monitoring the tumor progression and prognosis with/without various cancer therapeutic approaches.

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