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Abstract #3032

Novel Real-time Hyperpolarized 13C Metabolic Tracer Probes γ-Glutamyl Transferase Activities in vivo Tumor Xenografts

Tomohiro Seki1, Kazutoshi Yamamoto2, Nobu Oshima1, Marino Itoda3, Yohei Kondo3, Yutaro Saito3, Yoichi Takakusagi4, Shun Kishimoto1, Jeffrey R Brender1, Ronja M Malinowski5, Jan Henrik Ardenkjær-Larsen6, Hiroshi Nonaka3, Murali C Krishna1, and Shinsuke Sando3
1National Institutes of Health, Bethesda, MD, United States, 2National Cancer Institute, National Institutes of Health, Bethesda, MD, United States, 3University of Tokyo, Bunkyo ku, Japan, 4Quantum Medical Science, Chiba, Japan, 5Technical University of Denmark, Lyngby, Denmark, 6Department of Electrical Engineering, Technical University of Denmark, Lyngby, Denmark

It is well known that dysregulation of γ-glutamyl transferase (GGT) activities in malignant cells leads to more aggressive phenotypes by producing reactive oxygen species. GGT is important for glutathione homeostasis, and has also been used as a diagnostic marker for various pathologies in the liver, biliary system, and pancreas. Here, for the first time, a novel hyperpolarized 13C probe, γ-Glu-[1-13C]Gly, was demonstrated in in vivo tumor xenografts, including human pancreatic ductal adenocarcinoma and ovarian adenocarcinoma, to detect real-time γ-glutamyl transferase activities as a prospective biomarker for monitoring the tumor progression and prognosis with/without various cancer therapeutic approaches.

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