Downstream metabolic products from hyperpolarized pyruvate, such as lactate and bicarbonate, are acquired with coarse resolution for adequate SNR. However, the injected pyruvate exhibits high signal and can be acquired with higher resolution. A simulation framework has been developed to perform multi-resolution acquisitions of hyperpolarized [1-13C]pyruvate, which analyzes SNR and kinetic rate fits for differing resolution schemes. Utilizing the multi-resolution acquisition, lactate and bicarbonate have respective SNR improvement of 3.3-fold and 5.7-fold compared to high resolution images. Kinetic fits for multi-resolution images accurately estimated ground truth values. This simulation framework performed and analyzed variable resolution acquisitions to improve metabolic quantification.