Meeting Banner
Abstract #3033

Simulation and Application of a Variable Resolution Hyperpolarized 13C MRI Approach for Improved Quantification of Brain Metabolism

Jasmine Y. Graham1,2, Peder E.Z. Larson2, Daniel B. Vigneron2, and Jeremy W. Gordon2
1Bioengineering, UC San Francisco, UC Berkeley, San Francisco, CA, United States, 2Radiology and Biomedical Imaging, UC San Francisco, San Francisco, CA, United States

Downstream metabolic products from hyperpolarized pyruvate, such as lactate and bicarbonate, are acquired with coarse resolution for adequate SNR. However, the injected pyruvate exhibits high signal and can be acquired with higher resolution. A simulation framework has been developed to perform multi-resolution acquisitions of hyperpolarized [1-13C]pyruvate, which analyzes SNR and kinetic rate fits for differing resolution schemes. Utilizing the multi-resolution acquisition, lactate and bicarbonate have respective SNR improvement of 3.3-fold and 5.7-fold compared to high resolution images. Kinetic fits for multi-resolution images accurately estimated ground truth values. This simulation framework performed and analyzed variable resolution acquisitions to improve metabolic quantification.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here