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Abstract #3035

Simultaneous 19F hyperpolarization of aromatic molecules in aqueous solution

Frederike Euchner1, Christian Bruns1, Johannes Bernarding1, and Markus Plaumann1
1Institute of Biometrics and Medical Informatics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany

Fluorinated aromatic substrates are of high interest in biomedical and pharmaceutical applications. To increase the low 19F MR signal intensity in aqueous solutions, the hyperpolarization technique photo-Chemical Induced Dynamic Nuclear Polarization (photo-CIDNP) can be used. Compounds such as 2-fluoro-tyrosine, 3-fluoro-tyrosine or 3-fluoro-4-hydroxyphenylacetic acid were hyperpolarized repeatable inside the detection field (7T). Strong 19F signal enhancements could be detected for aromatic systems, which were fluorinated in meta-position. The simultaneous hyperpolarization of different substrates allows e.g. the study of molecule-molecule interactions and their binding behavior.

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