Fluorinated aromatic substrates are of high interest in biomedical and pharmaceutical applications. To increase the low 19F MR signal intensity in aqueous solutions, the hyperpolarization technique photo-Chemical Induced Dynamic Nuclear Polarization (photo-CIDNP) can be used. Compounds such as 2-fluoro-tyrosine, 3-fluoro-tyrosine or 3-fluoro-4-hydroxyphenylacetic acid were hyperpolarized repeatable inside the detection field (7T). Strong 19F signal enhancements could be detected for aromatic systems, which were fluorinated in meta-position. The simultaneous hyperpolarization of different substrates allows e.g. the study of molecule-molecule interactions and their binding behavior.
This abstract and the presentation materials are available to members only; a login is required.