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Abstract #3036

Development of Computational Methods for B1-Corrected Hyperpolarized 13C MRI Human Studies

Philip M Lee1, Hsin-Yu Chen2, Jeremy W Gordon2, Peder EZ Larson2, Mark Van Criekinge2, Michael A Ohliger2, Duan Xu2, John Kurhanewicz2, Robert A Bok2, Rahul Aggarwal3, Pamela N Munster3, and Daniel B Vigneron2
1Department of Radiology & Biomedical Imaging, University of California, San Francisco, Berkeley, CA, United States, 2Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 3Department of Medicine, University of California, San Francisco, San Francisco, CA, United States

The inhomogeneous B1 excitation profile of 13C surface transmit/receive coils results in a decreasing gradient of flip angles for voxels increasingly farther away from the coil. For accurately quantifying the pyruvate to lactate conversion rate (kPL), the flip angle needs to be corrected based on the B1 excitation profile. A voxel-wise B1 excitation field correction method for hyperpolarized 13C MRSI scans of human patients was developed and applied, yielding an improved quantitative accuracy of kPL values in metastatic cancer patients. The corrected kPL estimations agree with simulations where over-flip leads to an underestimation of kPL, whereas under-flip leads to overestimation.

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