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Abstract #3039

Progression towards in-vivo detection of Signal Amplification by Reversible Exchange (SABRE) Hyperpolarisation 

Aneurin J Kennerley1, Marie-Christine BD Labarthe1, Elizabeth J Fear1, Peter J Rayner1, and Simon B Duckett1
1Chemistry, University of York, York, United Kingdom

We demonstrate that signal amplification by reversible exchange (SABRE) presents as a promising and fast route to hyperpolarising a wide range of biologically relevant contrast agents, including nicotinamide (a precursor for NAD+ a mediator of metabolism) and pyruvate (for mapping anaerobic metabolism) for in-vivo preclinical magnetic resonance imaging and spectroscopic detection. Images recorded in a rat model at 7 Tesla (Bruker BioSpec 70/30) are presented. We highlight necessary chemical preparation steps to ensure that the SABRE agents are bio-compatible following exposure to high pressure para-hydrogen gas and the heavy metal Iridium catalyst required for SABRE hyperpolarisation.

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